Incidence of Narcolepsy in Germany.
Identifieur interne : 000130 ( Main/Exploration ); précédent : 000129; suivant : 000131Incidence of Narcolepsy in Germany.
Auteurs : Doris Oberle [Allemagne] ; Ursula Drechsel-B Uerle [Allemagne] ; Irene Schmidtmann [Allemagne] ; Geert Mayer [Allemagne] ; Brigitte Keller-Stanislawski [Allemagne]Source :
- Sleep [ 1550-9109 ] ; 2015.
Descripteurs français
- KwdFr :
- Adjuvants immunologiques, Adolescent, Adulte, Allemagne (épidémiologie), Enfant, Enfant d'âge préscolaire, Femelle, Grippe humaine (immunologie), Grippe humaine (virologie), Humains, Incidence, Jeune adulte, Mâle, Narcolepsie (diagnostic), Narcolepsie (épidémiologie), Nourrisson, Nouveau-né, Saisons, Sommeil, Sous-type H1N1 du virus de la grippe A (immunologie), Vaccination (), Vaccination (effets indésirables), Vaccins antigrippaux (effets indésirables), Vaccins antigrippaux (immunologie), Études rétrospectives.
- MESH :
- diagnostic : Narcolepsie.
- effets indésirables : Vaccination, Vaccins antigrippaux.
- immunologie : Grippe humaine, Sous-type H1N1 du virus de la grippe A, Vaccins antigrippaux.
- virologie : Grippe humaine.
- épidémiologie : Allemagne, Narcolepsie.
- Adjuvants immunologiques, Adolescent, Adulte, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Incidence, Jeune adulte, Mâle, Nourrisson, Nouveau-né, Saisons, Sommeil, Vaccination, Études rétrospectives.
English descriptors
- KwdEn :
- Adjuvants, Immunologic, Adolescent, Adult, Child, Child, Preschool, Female, Germany (epidemiology), Humans, Incidence, Infant, Infant, Newborn, Influenza A Virus, H1N1 Subtype (immunology), Influenza Vaccines (adverse effects), Influenza Vaccines (immunology), Influenza, Human (immunology), Influenza, Human (virology), Male, Narcolepsy (diagnosis), Narcolepsy (epidemiology), Retrospective Studies, Seasons, Sleep, Vaccination (adverse effects), Vaccination (statistics & numerical data), Young Adult.
- MESH :
- chemical , adverse effects : Influenza Vaccines.
- chemical , immunology : Influenza Vaccines.
- chemical : Adjuvants, Immunologic.
- adverse effects : Vaccination.
- diagnosis : Narcolepsy.
- epidemiology : Germany, Narcolepsy.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza, Human.
- statistics & numerical data : Vaccination.
- virology : Influenza, Human.
- Adolescent, Adult, Child, Child, Preschool, Female, Humans, Incidence, Infant, Infant, Newborn, Male, Retrospective Studies, Seasons, Sleep, Young Adult.
Abstract
STUDY OBJECTIVES
Following the 2009 pandemic, reports of an association between an AS03 adjuvanted H1N1 pandemic influenza vaccine and narcolepsy were published. Besides determining background incidence rates for narcolepsy in Germany this study aimed at investigating whether there was a change in incidence rates of narcolepsy between the pre-pandemic, pandemic, and the post-pandemic period on the population level.
DESIGN
Retrospective epidemiological study on the incidence of narcolepsy with additional capture-recapture analysis.
SETTING
German sleep centers.
PATIENTS OR PARTICIPANTS
Eligible were patients with an initial diagnosis of narcolepsy (ICD10 Code G47.4) within the period from January 1, 2007 to December 31, 2011.
INTERVENTIONS
None; observational study.
MEASUREMENTS AND RESULTS
A total of 342 sleep centers were invited to participate in the study. Adequate and suitable data were provided by 233 sleep centers (68.1%). A total of 1,198 patients with an initial diagnosis of narcolepsy within the observed period were included, of whom 106 (8.8%) were children and adolescents under the age of 18 years and 1,092 (91.2%) were adults. In children and adolescents, the age-standardized adjusted incidence rate significantly increased from 0.14/100,000 person-years in the pre-pandemic period to 0.50/100,000 person-years in the post-pandemic period (incidence density ratio, IDR 3.57; 95% CI 1.94-7.00). In adults, no significant change was detectable. This increase started in spring 2009.
CONCLUSIONS
For the years 2007-2011, valid estimates for the incidence of narcolepsy in Germany were provided. In individuals under 18, the incidence rates continuously increased from spring 2009.
DOI: 10.5665/sleep.5060
PubMed: 25902804
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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antigrippaux (immunologie)</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Adjuvants, Immunologic</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Vaccination</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Narcolepsy</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Narcolepsie</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Vaccination</term><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Germany</term><term>Narcolepsy</term></keywords><keywords scheme="MESH" 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Newborn</term><term>Male</term><term>Retrospective Studies</term><term>Seasons</term><term>Sleep</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adjuvants immunologiques</term><term>Adolescent</term><term>Adulte</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Incidence</term><term>Jeune adulte</term><term>Mâle</term><term>Nourrisson</term><term>Nouveau-né</term><term>Saisons</term><term>Sommeil</term><term>Vaccination</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>STUDY OBJECTIVES</b></p><p>Following the 2009 pandemic, reports of an association between an AS03 adjuvanted H1N1 pandemic influenza vaccine and narcolepsy were published. Besides determining background incidence rates for narcolepsy in Germany this study aimed at investigating whether there was a change in incidence rates of narcolepsy between the pre-pandemic, pandemic, and the post-pandemic period on the population level.</p></div><div type="abstract" xml:lang="en"><p><b>DESIGN</b></p><p>Retrospective epidemiological study on the incidence of narcolepsy with additional capture-recapture analysis.</p></div><div type="abstract" xml:lang="en"><p><b>SETTING</b></p><p>German sleep centers.</p></div><div type="abstract" xml:lang="en"><p><b>PATIENTS OR PARTICIPANTS</b></p><p>Eligible were patients with an initial diagnosis of narcolepsy (ICD10 Code G47.4) within the period from January 1, 2007 to December 31, 2011.</p></div><div type="abstract" xml:lang="en"><p><b>INTERVENTIONS</b></p><p>None; observational study.</p></div><div type="abstract" xml:lang="en"><p><b>MEASUREMENTS AND RESULTS</b></p><p>A total of 342 sleep centers were invited to participate in the study. Adequate and suitable data were provided by 233 sleep centers (68.1%). A total of 1,198 patients with an initial diagnosis of narcolepsy within the observed period were included, of whom 106 (8.8%) were children and adolescents under the age of 18 years and 1,092 (91.2%) were adults. In children and adolescents, the age-standardized adjusted incidence rate significantly increased from 0.14/100,000 person-years in the pre-pandemic period to 0.50/100,000 person-years in the post-pandemic period (incidence density ratio, IDR 3.57; 95% CI 1.94-7.00). In adults, no significant change was detectable. This increase started in spring 2009.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>For the years 2007-2011, valid estimates for the incidence of narcolepsy in Germany were provided. In individuals under 18, the incidence rates continuously increased from spring 2009.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">25902804</PMID><DateCompleted><Year>2016</Year><Month>03</Month><Day>10</Day></DateCompleted><DateRevised><Year>2018</Year><Month>12</Month><Day>02</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1550-9109</ISSN><JournalIssue CitedMedium="Internet"><Volume>38</Volume><Issue>10</Issue><PubDate><Year>2015</Year><Month>Oct</Month><Day>01</Day></PubDate></JournalIssue><Title>Sleep</Title><ISOAbbreviation>Sleep</ISOAbbreviation></Journal><ArticleTitle>Incidence of Narcolepsy in Germany.</ArticleTitle><Pagination><MedlinePgn>1619-28</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.5665/sleep.5060</ELocationID><Abstract><AbstractText Label="STUDY OBJECTIVES" NlmCategory="OBJECTIVE">Following the 2009 pandemic, reports of an association between an AS03 adjuvanted H1N1 pandemic influenza vaccine and narcolepsy were published. Besides determining background incidence rates for narcolepsy in Germany this study aimed at investigating whether there was a change in incidence rates of narcolepsy between the pre-pandemic, pandemic, and the post-pandemic period on the population level.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">Retrospective epidemiological study on the incidence of narcolepsy with additional capture-recapture analysis.</AbstractText><AbstractText Label="SETTING" NlmCategory="METHODS">German sleep centers.</AbstractText><AbstractText Label="PATIENTS OR PARTICIPANTS" NlmCategory="METHODS">Eligible were patients with an initial diagnosis of narcolepsy (ICD10 Code G47.4) within the period from January 1, 2007 to December 31, 2011.</AbstractText><AbstractText Label="INTERVENTIONS" NlmCategory="METHODS">None; observational study.</AbstractText><AbstractText Label="MEASUREMENTS AND RESULTS" NlmCategory="RESULTS">A total of 342 sleep centers were invited to participate in the study. Adequate and suitable data were provided by 233 sleep centers (68.1%). A total of 1,198 patients with an initial diagnosis of narcolepsy within the observed period were included, of whom 106 (8.8%) were children and adolescents under the age of 18 years and 1,092 (91.2%) were adults. In children and adolescents, the age-standardized adjusted incidence rate significantly increased from 0.14/100,000 person-years in the pre-pandemic period to 0.50/100,000 person-years in the post-pandemic period (incidence density ratio, IDR 3.57; 95% CI 1.94-7.00). In adults, no significant change was detectable. This increase started in spring 2009.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">For the years 2007-2011, valid estimates for the incidence of narcolepsy in Germany were provided. In individuals under 18, the incidence rates continuously increased from spring 2009.</AbstractText><CopyrightInformation>© 2015 Associated Professional Sleep Societies, LLC.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Oberle</LastName><ForeName>Doris</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department Safety of Medicinal Products and Medical Devices, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Langen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Drechsel-Bäuerle</LastName><ForeName>Ursula</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Department Safety of Medicinal Products and Medical Devices, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Langen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmidtmann</LastName><ForeName>Irene</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>IMBEI Institute of Medical Biometry, Epidemiology and Informatics, Johannes Gutenberg University of Mainz, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mayer</LastName><ForeName>Geert</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Hephata-Klinik, Schwalmstadt-Treysa, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Keller-Stanislawski</LastName><ForeName>Brigitte</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department Safety of Medicinal Products and Medical Devices, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Langen, Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D064888">Observational Study</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>10</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Sleep</MedlineTA><NlmUniqueID>7809084</NlmUniqueID><ISSNLinking>0161-8105</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000276">Adjuvants, Immunologic</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000276" MajorTopicYN="N">Adjuvants, Immunologic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005858" MajorTopicYN="N">Germany</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 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IdType="pubmed">23884811</ArticleId></ArticleIdList></Reference><Reference><Citation>Sleep Med. 2013 Sep;14(9):867-71</Citation><ArticleIdList><ArticleId IdType="pubmed">23773727</ArticleId></ArticleIdList></Reference><Reference><Citation>J Intern Med. 2014 Feb;275(2):172-90</Citation><ArticleIdList><ArticleId IdType="pubmed">24134219</ArticleId></ArticleIdList></Reference><Reference><Citation>Euro Surveill. 2014;19(17):15-25</Citation><ArticleIdList><ArticleId IdType="pubmed">24821121</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Oberle, Doris" sort="Oberle, Doris" uniqKey="Oberle D" first="Doris" last="Oberle">Doris Oberle</name></noRegion><name sortKey="Drechsel B Uerle, Ursula" sort="Drechsel B Uerle, Ursula" uniqKey="Drechsel B Uerle U" first="Ursula" last="Drechsel-B Uerle">Ursula Drechsel-B Uerle</name><name sortKey="Keller Stanislawski, Brigitte" sort="Keller Stanislawski, Brigitte" uniqKey="Keller Stanislawski B" first="Brigitte" last="Keller-Stanislawski">Brigitte Keller-Stanislawski</name><name sortKey="Mayer, Geert" sort="Mayer, Geert" uniqKey="Mayer G" first="Geert" last="Mayer">Geert Mayer</name><name sortKey="Schmidtmann, Irene" sort="Schmidtmann, Irene" uniqKey="Schmidtmann I" first="Irene" last="Schmidtmann">Irene Schmidtmann</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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